Antiviral compounds and methods

A method for preventing the infection of a cell exposed to a virus or for reducing, retarding or otherwise inhibiting growth and/or replication of a virus in a cell infected with said virus comprising contacting the cell with a compound of Formula I

• or a pharmaceutically acceptable salt thereof,
• wherein,
• R2, R3 and R4 are independently hydrogen,
• and wherein
• X=hydrogen, hydroxy, nitro, halo, C1-6alkyl, C1-6alkyloxy, C3-6cycloalkyl, halo-substituted C1-6alkyl, halo-substituted C1-6alkyloxy, phenyl, C1-6alkeneyl, C3-6cycloalkeneyl, C1-6alkeneoxy, or benzo;
• Rd, Re, Rf, Rh, Rk, RL, Rm, Rn, Ro, Rp independently=hydrogen, amino, halo, C1-5alkyl, C1-5alkyloxy, hydroxy, aryl, substituted aryl, substituted amino, mono or dialkyl-substituted amino, cycloalkyl-substituted amino, aryl-substituted amino,
• or PrS;
• Rg, Ri independently=hydrogen, hydroxy, halo, or C1-5 alkyl;
• Rj=hydrogen, amino, halo, C1-5 alkyl, C1-5 alkyloxy, hydroxy, aryl, substituted aryl, substituted amino, alkyl-substituted amino, cycloalkyl-substituted amino, aryl-substituted amino, PrS,
• and wherein
• when R1 is C6H5CH═CH, R2 is hydrogen and R3 is phenyl, R4 cannot be phenyl;
• when R1 is phenyl, R2 is hydrogen, and R3 is benzoyl, R4 cannot be benzoyl;
• when R1 is phenyl, R2 is substituted benzyl, R3 is hydrogen and R4 is hydrogen, Rn, Ro and Rp cannot all be hydrogen;
• when R1 is phenyl, R3 is hydrogen and R4 is hydrogen, R2 cannot be benzyl or phenyl;
• when R1 is phenyl, R2 is hydrogen, R3 cannot be phenyl together with R4 as benzoyl;
• and
• when R1 is phenyl, R2 is hydrogen, R3 and R4 cannot both be benzyl, wherein said virus is a Lentivirus, Human Immunodeficiency Virus (HIV), a Coronavirus, the Hepatitis C virus or Equine Arteritis virus.