Substituted triazenes protected from degradation by carboxylation of N1
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsJohn C. Jewett, Lindsay E. Guzman, Flora W. Kimani, Bereketab T. Mehari, Mehrdad Shadmehr
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Abstract
Triazabutadiene molecules for use in applications. e.g., those involving fluorogenic molecules, e.g., triazabutadiene molecules configured to generate a fluorescent compound when combined with a second molecule, e.g., upon reaction with a tyrosine molecule or other appropriate molecule; and protected triazabutadiene molecules that are stable in acidic conditions and are adapted to release an active (e.g., acid-labile} triazabutadiene molecule upon appropriate conditions, and methods for producing and using said protected or releasable triazabutadiene molecules (and products of cleavage).
Claims4
A compound of Formula B:
- wherein:
- A is —N—;
- D is —H;
- E is —H;
- X1 is 2,4,6-trimethylphenyl;
- Y1 is 2,4,6-trimethylphenyl;
- Z1 is phenyl, optionally substituted with a substituent selected from the group consisting of —NO2, C1-6 alkyl, C1-6 haloalkyl, —OC1-6 alkyl, —C(O)OH and —C(O)OC1-6 alkyl;
- and
- Z2 is —C(O)OC1-6 alkyl, wherein the C1-6 alkyl is optionally substituted with a substituent selected from the group consisting of aryl and heterocyclyl, wherein the aryl is optionally substituted with one, two or three substituents independently selected from the group consisting of —NO2, —C(O)O−, —OC1-6 alkyl and —NHC(O)CH2Ph and the heterocyclyl is optionally substituted with one, two or three substituents independently selected from the group consisting of oxo, —NO2, —C(O)O−, —OC1-6 alkyl and —NHC(O)CH2Ph.
Dependencies are inferred from the claim text.