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US 10,472,329 B2Granted
Process for the preparation of intermediates useful in the synthesis of Eluxadoline
AssigneeAllergan Holdings Unlimited Company
InventorsParven Kumar Luthra, Chandrasekhar Sinha, Syed Aziz Imam Quadri, Tonmoy Chitta Das
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Abstract
The invention relates to an improved process for preparing [(S)-1-(4-phenyl-1-H-imidazol-2-yl)-ethyl]-amine. The process involves formation of the novel intermediate crystalline compound [(S)-1-(4-phenyl-1-H-imidazol-2-yl)-ethyl]-carbamic acid tert-butyl ester oxalate.
Claims4
An oxalate salt of a compound with the formula
- wherein Gp is an amino protecting group and thus Gp-NH in the formula is formed from the group consisting of 9-fluorenylmethyl carbamate (FMOC amide), t-butyl carbamate (BOC amide), benzyl carbamate, acetamide, trifluoroacetamide, phthalimide, benzylamine, triphenylmethylamine, benzylideneamine, and tosylamide.
Crystalline [(S)-1-(4-phenyl-1-H-imidazol-2-yl)-ethyl]-carbamic acid tert-butyl ester oxalate.
Dependencies are inferred from the claim text.