PQSR modulators

A compound of the following formula:

• or a pharmacologically acceptable salt thereof, wherein
• R1 is a C6- or C7 alkyl group, in which one or two non-adjacent CH2 group(s) may be replaced by O;
• R2 represents (C1-3 alkyl)OH;
• (C1-3 alkyl)O(C1-3 alkyl);
• —C(═O)O(CH2)CH3;
• or —C(═O)NHOH;
• R3 represents H, halogen atom, CN, CF3, NO2, NH2, —NHC(═O)R4, —NHSO2R4, (CH2)mOR4, SOCH3, SOCN, SOCF3, SO2CH3, SO2CN, SO2CF3, SO2NR5R6, C(═O)OC1-6 alkyl, C(═O)NR5R6, COCH3, COCF3, or C(CN)3;
• R4 in each case, independently of one another, represents a hydrogen atom;
• an alkyl;
• alkenyl;
• alkynyl;
• heteroalkyl;
• cycloalkyl;
• heterocycloalkyl;
• aryl;
• heteroaryl;
• aralkyl;
• or heteroaralkyl group;
• R5 and R6 each independently represents a hydrogen atom;
• a methyl, an ethyl or an isopropyl group;
• or R5 and R6 are taken together to form a 5- to 8-membered saturated, unsaturated or aromatic heterocycle containing 1 to 4 N atoms or 1 to 3 heteroatoms selected from the group consisting of nitrogen, oxygen and sulphur, which heterocycle may be unsubstituted or mono-, di or trisubstituted by a halogen atom or R;
• or R5 and R6 are taken together to form a 5- to 8-membered saturated, unsaturated or aromatic heterocycle containing 1 to 3 heteroatoms selected from the group consisting of nitrogen, oxygen and sulphur, which is fused to one or two rings selected from the group consisting of cycloalkyl;
• heterocycloalkyl;
• alkylcycloalkyl;
• heteroalkylcycloalkyl;
• aryl;
• heteroaryl;
• aralkyl;
• and heteroaralkyl;
• R represents H;
• —(CH2)p-L;
• —(CH2)p—OL;
• a C1-6 heteroalkyl;
• a cycloalkyl;
• a heterocycloalkyl;
• an alkylcycloalkyl;
• a heteroalkylcycloalkyl;
• an aryl;
• a heteroaryl;
• an aralkyl;
• or a heteroaralkyl group;
• and
• m represents an integer from 1 to 6.