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US 10,471,398 B2Granted
Graft copolymer functionalized article
Assignee3M Innovative Properties Company
InventorsCatherine A. Bothof, George W. Griesgraber, James I. Hembre, Jerald K. Rasmussen
Life of this patent
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Abstract
Guanidinyl ligand-functionalized polymers, methods of making the same, and substrates bearing a grafted coating of the ligand-functional polymers are described. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, endotoxins and proteins, at pH's near or below the pI's of the biomaterials.
Claims5
An article comprising:
- a) a substrate;
- and
- b) grafted to the surface of the substrate is a (co)polymer comprising polymerized ligand functional monomer units of the formula:
- wherein:
- R1 is H or C1-C4 alkyl;
- R2 is a (hetero)hydrocarbyl group;
- each R3 is independently H or hydrocarbyl;
- R4 is H, C1-C12 alkyl or N(R3)2;
- R5 is H or hydrocarbyl;
- X1 is —O— or —NR3—;
- o is 0 or 1;
- and
- n is 1 or 2;
- and
- wherein the (co)polymer consists of the formula:
- -(MLig)y-(MHydrophil)x-(Mcrosslink)z-,
- wherein:
- (MLig)y are the ligand functional monomer units having “y” polymerized monomer units where y is 10 to 100 parts by weight;
- (MHydrophil)x are hydrophilic monomer units having “x” polymerized monomer units where x is 0 to 90 parts by weight;
- (Mcrosslink)z are multifunctional (meth)acrylate monomer units having “z” polymerized monomer units where z is 0 to 5 parts by weight, and where the total of x plus y plus z is 100 parts by weight.
17 more elements
Dependencies are inferred from the claim text.