Compositions and methods for the treatment of xerostomia
AssigneeColgate-Palmolive Company
InventorsRajnish Kohli, Richard Scott Robinson, Richard J. Sullivan, Diane Cummins, Nagaraja Jayaraman, MaryAnn Filadelfi-Keszi
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Abstract
The present invention is directed to methods and compositions comprising a basic amino acid, e.g., arginine, for the treatment of dry mouth.
Claims16
A method to treat, ameliorate, inhibit, or prevent dry mouth in a person that either has xerostomia, is diagnosed with a disease or injury that predisposes the person to xerostomia or is being treated with a medication that predisposes the person to xerostomia, the method comprising administering to the oral cavity of the person a composition comprising a basic amino acid, in free or salt form, and zinc citrate;
- wherein the basic amino acid is arginine or arginine bicarbonate, and the arginine is L-arginine;
- and
- wherein the composition further comprises one or more compounds selected from the group consisting of:
- (a) a calcium ion source;
- (b) a phosphate ion source;
- (c) a potassium ion source;
- (d) a magnesium ion source;
- (e) a fluoride ion source;
- (f) a flavorant which promotes saliva flow;
- and
- (g) a polyol humectant;
- and
- wherein the fluoride ion source is selected from stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations thereof, and
- wherein the composition has a pH between about 6.8 and 7.2.
Dependencies are inferred from the claim text.