Method and apparatus for calibrating dorsal horn stimulation using sensors

A system for applying neuromodulation to a patient having a nervous system including a dorsal horn, a dorsal root, and a dorsal column, the system comprising:

• a modulation output circuit configured to deliver dorsal horn stimulation to the dorsal horn and to deliver dorsal root stimulation to the dorsal root;
• and
• a modulation control circuit configured to control the delivery of the dorsal horn stimulation and the dorsal root stimulation using a plurality of modulation parameters, wherein a neurophysiological response of the dorsal column to the dorsal root stimulation is modulated by the dorsal horn stimulation during the delivery of the dorsal horn stimulation interleaved with the dorsal root stimulation, the modulation control circuit including:
• a response input configured to receive response information including one or more response parameters derived from a sensor configured to sense a quantitative measure of the neurophysiological response of the dorsal column to the dorsal root stimulation modulated by the dorsal horn stimulation during the delivery of the dorsal horn stimulation interleaved with the dorsal root stimulation;
• and
• a parameter calibrator configured to adjust one or more modulation parameters of the plurality of modulation parameters using the response information.