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US 10,471,184 B2Granted
Coating formulations for scoring or cutting balloon catheters
AssigneeAngioScore, Inc.
InventorsUlrich Speck, Madeline Caroline Berg
Life of this patent
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Abstract
The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one drug or drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein a combination of the at least one drug being a limus drug and the at least one lipophilic antioxidant being butylated hydroxytoluene is excluded.
Claims20
A method of manufacturing a medical device for use in angioplasty or coronary angioplasty, comprising:
- providing a balloon catheter, the balloon catheter comprising:
- a shaft having a proximal portion and a distal portion;
- an inflatable balloon coupled to the distal portion of the shaft;
- a nonimplantable scoring structure surrounding the balloon;
- and
- spraying a coating composition onto at least a portion of a surface of the balloon catheter, the coating composition comprising at least one drug and at least one lipophilic antioxidant, the coating composition being 3-100% by weight of the at least one drug, wherein the at least one drug is selected from the group consisting of a Limus drug, a cell proliferation inhibitor, and an inhibitor of neovascularization, wherein the at least one lipophilic antioxidant is selected from the group consisting of butylated hydroxytoluene, butylated hydroxyanisole, nordihydroguaiaretic acid, ascorbyl palmitate, and propyl gallate, wherein a combination of a Limus drug with butylated hydroxytoluene as the lipophilic antioxidant is excluded, wherein the at least one lipophilic antioxidant protects the at least one drug from premature loss.
3 more elements
Dependencies are inferred from the claim text.