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US 10,471,181 B2Granted
Fiber-hydrogel composite surgical meshes for tissue repair
AssigneeThe Johns Hopkins University
InventorsRussell Martin, Sashank Reddy, Justin Sacks, Xiaowei Li, Brian Honewee Cho, Hai-quan Mao
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Abstract
The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of laminar composite is disclosed for the purpose of reducing foreign body response, managing tissue-materials interface, and improving the integration of the surgical mesh with the surrounding tissue of a subject.
Claims25
A surgical scaffold device comprising a laminar scaffold complex, comprising:
- polymeric fibers having a mean diameter of from 100 nm to 8000 nm covalently linked to a hydrogel material, wherein:
- a) the polymeric fibers are dispersed throughout the hydrogel material;
- b) the scaffold complex comprises a reacted crosslinking moiety;
- c) the scaffold complex comprises a plurality of pores present on or within a surface of the scaffold complex, wherein the pores are present at a concentration of at least 50 pores per cm2, and wherein at least 80% of the pores have an average pore diameter of at least 5 microns;
- d) the device is configured in a geometry suitable for implantation in an organ or tissue selected from skin, fascia, pleura, dura, pericardium, paratenon, periosteum, perineurium, blood vessel wall, and lymphatic wall;
- and
- e) the device is configured as a sheet having a first dimension and a second dimension independently at least five times as great in length as a third dimension.
4 more elements
A surgical device comprising:
- i) a laminar scaffold complex comprising polymeric fibers having a mean diameter of from 100 nm to 8000 nm covalently linked to a hydrogel material;
- wherein the polymeric fibers are dispersed throughout the hydrogel material,
- the scaffold complex comprises a reacted crosslinking moiety,
- the scaffold complex comprises a plurality of pores present on or within a surface of the scaffold complex, wherein the pores are present at a concentration of at least 50 pores per cm2, and wherein at least 80% of the pores have an average pore diameter of at least 5 microns;
- ii) a surgical mesh material;
- wherein the surgical mesh material is covalently linked to the laminar scaffold complex, and wherein the surgical mesh material is disposed over all or a portion of the laminar scaffold complex.
3 more elements
Dependencies are inferred from the claim text.