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US 10,471,177 B2Granted
Surface modified biological materials
AssigneeOrthobond, Inc.
InventorsRandell Clevenger, Rong Dong, Jordan Katz
Life of this patent
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Abstract
Disclosed in certain embodiments is a composition comprising a biological material and transition metal atoms selected from the group consisting of Group IVB, Group VB, Group VIB of the Periodic Chart and a combination thereof, bound to a surface of the biological material.
Claims21
A method of treating biological material comprising contacting biological material with oxygen plasma to form activated biological material, wherein the biological material is a acellular dermal tissue;
- bonding transition metal atoms selected from the group consisting of Group IVB, Group VB, Group VIB of the Periodic Chart and a combination thereof, to the activated biological material,
- bonding an inorganic phosphate, organic phosphinate or organic phosphonate to the transition metal atoms;
- and
- reacting the inorganic phosphate, organic phosphinate or organic phosphonate with a coupling agent and a pharmacological agent,
- wherein the acellular dermal tissue has less than 3% by weight viable cells based on the total weight of the acellular dermal tissue;
- and/or wherein the acellular dermal tissue has less than 25% by weight nucleic acid based on the total weight of the acellular dermal tissue.
3 more elements
Dependencies are inferred from the claim text.