Ophthalmic solution

An ophthalmic solution consisting of:

• (A) hydroxypropyl methylcellulose having 28.0 to 30.0 mass % methoxy groups and 7.0 to 12.0 mass % hydroxypropoxy groups, both with respect to a total amount of said hydroxypropyl methylcellulose, at a methoxy group/hydroxypropoxy group ratio of 2.5 to 4.0 by mass, wherein a 2 mass % aqueous solution of said hydroxypropyl methylcellulose at 20° C. has a viscosity of 50 to 4000 mPa·s;
• (B) sodium chloride or potassium chloride;
• (C) hexamethylene biguanide represented by formula (1) or a salt thereof:
• wherein k denotes the number of repeating units and is an integer of 3 to 40;
• (D) 2-methacryloyloxyethyl phosphorylcholine/butyl methacrylate copolymer represented by formula (2):
• wherein m and n each denotes a molar ratio of respective constitutional unit, and m/n is 70/30 to 90/10 by mole;
• and
• (E) water;
• and
• optionally one or more components selected from the group consisting of boric acid, borax, disodium edetate dihydrate, sodium hydrogen phosphate hydrate, sodium dihydrogen phosphate anhydrous, and sodium hydroxide;
• wherein a content of (A) is 0.1 to 0.2% w/v, a content of (B) is 0.01 to 1.5% w/v, a content of (C) is 0.00005 to 0.00015% w/v, and a content of (D) is 0.05 to 0.15% w/v, all with respect to a total amount of said ophthalmic solution.