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US 10,471,163 B2Granted
Activatable fibrin-binding probes
AssigneeThe General Hospital Corporation
InventorsGalen Loving, Peter D. Caravan
Life of this patent
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Abstract
Provided herein are methods for determining the presence or absence of active thrombus formation using a linear polypeptide that binds fibrin upon cyclization. Also provided are compounds comprising linear polypeptide probes that are cyclized in the presence of protein disulfide isomerase.
Claims2
A compound, which is:
- or a pharmaceutically acceptable salt thereof, wherein:
- X1 and X2 are each
- and Y is
Dependencies are inferred from the claim text.