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US 10,471,153 B2Granted
Ice-based lipid nanoparticle formulation for delivery of mRNA
AssigneeTranslate Bio, Inc.
InventorsFrank DeRosa, Michael Heartlein, Shrirang Karve
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Abstract
The present invention provides, among other things, compositions and methods of formulating nucleic acid-containing nanoparticles comprising no more than three distinct lipids components, one distinct lipid component being a sterol-based cationic lipid. In some embodiments, the present invention provides compositions and methods in which the lipid nanoparticles further comprise helper lipids and PEG-modified lipids. The resulting formulation comprises a high encapsulation percentage for nucleic acids.
Claims6
A composition comprising:
- nucleic acids;
- and
- lipid nanoparticles encapsulating the nucleic acids, wherein each individual lipid nanoparticle comprises no more than three distinct lipid components, one distinct lipid component being a sterol-based cationic lipid comprising imidazole cholesterol ester (ICE),
- wherein the sterol-based cationic lipid constitutes less than 70% molar ratio of the total lipids, and
- further wherein the lipid nanoparticles have an encapsulation percentage for nucleic acids of at least 70%.
2 more elements
Dependencies are inferred from the claim text.