Material and method for treating internal cavities
AssigneeUrogen Pharma Ltd.
InventorsMarina Konorty, Gil Hakim
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Abstract
Disclosed herein are materials, means and methods for sustained release of therapeutic agents for topical treatments. In particular, disclosed are means and methods for topical treatment of diseases of internal body cavities by embedding therapeutic agents in a slowly degrading biocompatible mixture applied to affected tissue.
Claims13
A method for treating a patient with a bladder disorder characterized by bladder spasms, comprising:
- preparing a pharmaceutical composition by incorporating into a biocompatible mucoadhesive thermoreversible hydrogel a therapeutically effective amount of at least one pharmaceutically active agent selected from the group of neurological blocking agents comprising botulinum toxin, botulinum toxin A, botulinum toxin B, botulinum toxin Cl, botulinum toxin D, botulinum toxin E, botulinum toxin F, botulinum toxin G;
- and
- instilling said pharmaceutical composition into the urinary tract of the patient suffering from the bladder disorder;
- wherein said instilling is at a temperature at which the pharmaceutical composition is liquid;
- whereby the pharmaceutical composition gels in contact with an internal wall of the urinary tract;
- wherein the method does not comprise any step of injecting a pharmaceutically active agent into a wall of the bladder;
- and
- wherein the pharmaceutical composition has a viscosity of greater than 3000 Pa·s at 37° C.
A method for treating urinary incontinence, overacting bladder, interstitial cystitis, urge incontinence, and any bladder pathologies which involve bladder disorders, the method comprising administering to a subject in need of such treatment a pharmaceutical composition comprising a biocompatible mucoadhesive thermoreversible hydrogel and a therapeutically effective amount of an active agent comprising at least one neurological blocking agent selected from the group consisting of botulinum toxin of botulinum toxin A, botulinum toxin B, botulinum toxin Cl, botulinum toxin D, botulinum toxin E, botulinum toxin F, and botulinum toxin G;
- wherein the step of administering comprises:
- instilling into the urinary tract of the subject the biocompatible mucoadhesive thermoreversible hydrogel at a temperature at which the pharmaceutical composition is liquid;
- whereby the pharmaceutical composition gels at body temperature in contact with an internal wall of urinary tract;
- and wherein the mucoadhesive thermoreversible hydrogel composition has a viscosity of less than 200 Pa s at 10° C. and greater than 3000 Pa s at 37° C.
Dependencies are inferred from the claim text.