Stabilized vancomycin formulations
AssigneeInsmed Incorporated
InventorsWalter Perkins, Vladimir Malinin
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Abstract
In one aspect, the invention provides a stabilized lipid-based glycopeptide antibiotic composition and a process for producing the same. In another aspect, the invention provides methods for treating a bacterial pulmonary infection by administering to a subject in need thereof a therapeutically effective amount of the stabilized lipid-based glycopeptide antibiotic composition.
Claims18
A stabilized lipid-based glycopeptide antibiotic composition comprising:
- a lipid component;
- a glycopeptide antibiotic;
- and
- an amino acid or a derivative thereof selected from the group consisting of gamma-aminobutyric acid (GABA), D-alanine (D-ALA), D-glutamic acid (D-GLU), aspartic acid (ASP), D-aspartic acid (D-ASP), bicine, tricine, iminodiacetic acid (IDAA), glycylgiycine (Gly-Gly), and glutamic acid (GLU),
- wherein the amino acid or the derivative thereof reduces the degradation rate of the glycopeptide antibiotic.
A method for treating a bacterial infection in a patient in need thereof, the method comprising administering to the patient, a therapeutically effective amount of a stabilized lipid-based glycopeptide antibiotic composition comprising a lipid component, a glycopeptide antibiotic, and an amino acid or derivative thereof, wherein the amino acid or the derivative thereof is selected from the group consisting of gamma-aminobutyric acid (GABA), D-alanine (D-ALA), D-glutamic acid (D-GLU), aspartic acid (ASP), D-aspartic acid (D-ASP), bicine, tricine, iminodiacetic acid (IDAA), glycylgiycine (Gly-Gly), and glutamic acid (GLU) and the amino acid or the derivative thereof reduces the degradation rate of the glycopeptide antibiotic.
Dependencies are inferred from the claim text.