Methods for treating cancer using nanoparticle complexes of paclitaxel, rituximab, and albumin

A method for treating cancer in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically acceptable carrier and antibody-albumin nanoparticle complexes, said complexes comprising albumin, a rituximab antibody, and paclitaxel, wherein the nanoparticle complexes have been pre-formed in vitro by mixing aqueous albumin-paclitaxel nanoparticies with the antibody under conditions to form the nanoparticle complexes, such that the nanoparticle complexes have CD20 binding specificity, wherein the cancer expresses CMG, and wherein the average diameter of said complexes is between 0.1 μm and 1 μm.