Back to results
US 10,471,132 B2Granted
Treatment of hyperbilirubinemia
AssigneesGenethon, International Centre for Genetic Engineering and Biotechnology
InventorsFederico Mingozzi, Giuseppe Ronzitti, Fanny Collaud, Andrés Muro, Giulia Bortolussi
Life of this patent
Estimating the term…
Abstract
The invention relates to a nucleic acid sequence useful in the treatment of hyperbilirubinemia, in particular in the treatment of Crigler-Najjar syndrome. More particularly, the nucleic acid sequence of the present invention is a codon-optimized UGT1A1 coding sequence.
Claims19
An isolated nucleic acid sequence comprising the nucleotide sequence as set forth in SEQ ID NO:
- 2 or SEQ ID NO:
- 3, wherein said isolated nucleic acid sequence encodes UDP-glucuronosyltransferase isozyme 1A1 (UGT1A1).
Dependencies are inferred from the claim text.