Topical therapeutic formulations
AssigneeHybrid Medical, LLC
InventorsJeff Twidwell, Joel Buckley, Harold Hoium
Life of this patent
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Abstract
The invention provides topical compositions and methods for using the compositions. The compositions can be used for the treatment of fibrotic or connective tissue disorders involving scarring, sub-dermal plaque accumulations, or fibrosis of muscle tissue. The disorders can be painlessly treated by the topical application of a composition described herein. One or more calcium channel blocker agents can serve as an active ingredient of the compositions, optionally in combination with, for example, one or more of emu oil and superoxide dismutase. The composition can further include pharmaceutically acceptable carriers that can facilitate the non-invasive transdermal delivery of the active(s) to subdermal sites.
Claims20
A composition suitable for topical application to the skin and transdermal delivery, comprising:
- nanoparticles comprising a composition comprising 15 wt. % to 30 wt. % of a dihydropyridine by weight in the total composition and 0.05 wt. % to 3 wt. % of a superoxide dismutase by weight in the total composition, 60 wt. % to 85 wt. % emu oil by weight in the total composition, and one or more pharmaceutically acceptable carriers or gelling agents, wherein the dihydropyrdine comprises amlodipine, benidipine, clevidipine, isradipine, felodipine, nicardipine, nifedipine, nilvadipine, nimodipine, nisoldipine, or nitrendipine.
A composition suitable for topical application to the skin and transdermal delivery, comprising:
- a composition comp rising 15 wt. % to 30 wt. % of a dihydropyridine by weight in the total composition and 0.05 wt. % to 3 wt. % of a superoxide dismutase by weight in the total composition, 60 wt. % to 85 wt. % emu oil by weight in the total composition, and one or more pharmaceutically acceptable carriers or gelling agents, wherein the dihydropyrdine comprises amlodipine, benidipine, clevidipine, isradipine, felodipine, nicardipine, nifedipine, nilvadipine, nimodipine, nisoldipine, or nitrendipine.
Dependencies are inferred from the claim text.