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US 10,471,124 B2Granted
Proteinaceous heterodimer and use thereof
AssigneeDingfu Biotarget Co., Ltd.
InventorsTing Xu, Yan Luan, Jianjian Peng, Shuli Ma, Meng Zhao, Xiaoxiao Wang, Hui Ma, Shilong Fu, Xiaolong Pan, Shanshan Ning
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Abstract
The present disclosure provides proteinaceous heterodimers, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous heterodimers, methods for producing the proteinaceous heterodimers, and uses thereof.
Claims3
A proteinaceous complex, comprising (i) a light chain and a heavy chain of an antibody;
- and (ii) a fusion polypeptide comprising, from N-terminus to C-terminus, an immunoregulator fused to an antibody Fc region, optionally via a linker;
- wherein said light chain of the antibody and said heavy chain of the antibody respectively comprises an amino acid sequence as set forth in:
- SEQ ID NO:
- 11 and SEQ ID NO:
- 13, SEQ ID NO:
- 15 and SEQ ID NO:
- 17, SEQ ID NO:
- 55 and SEQ ID NO:
- 53, or SEQ ID NO:
- 65 and SEQ ID NO:
- 67;
- and
- said fusion polypeptide comprises an amino acid sequence as set forth in SEQ ID NO:
- 1, SEQ ID NO:
- 3, SEQ ID NO:
- 5, SEQ ID NO:
- 7, SEQ ID NO:
- 9, SEQ ID NO:
- 49, or SEQ ID NO:
- 51.
17 more elements
Dependencies are inferred from the claim text.