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US 10,471,108 B2Granted
Compositions comprising bacterial strains
Assignee4D Pharma Research Limited
InventorsImke Elisabeth Mulder, Amy Beth Holt, Seanin Marie McCluskey, Grainne Clare Lennon, Suaad Ahmed
Life of this patent
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Abstract
The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.
Claims20
A pharmaceutical composition that comprises an amount of a bacteria strain of the species Enterococcus faecium;
- wherein said Enterococcus faecium is the sole species present in the pharmaceutical composition in an amount that is greater than 1×106 CFU/g with respect to a total weight of the pharmaceutical composition;
- wherein the Enterococcus faecium bacteria strain is live and lyophilized;
- and wherein the Enterococcus faecium bacteria strain has an enzyme profile as determined by a Rapid ID 32A analysis that is:
- (i) positive for at least one of:
- arginine dihydrolase, β-glucosidase, mannose fermentation, glutamic acid decarboxylase, arginine arylamidase, phenylalanine arylamidase, leucine arylamidase, pyroglutamic acid arylamidase, tyrosine arylamidase, glycine arylamidase, histidine arylamidase and serine arylamidase;
- and
- (ii) intermediate for N-acetyl-β-glucosaminidase.
4 more elements
A pharmaceutical composition that comprises an amount of a bacteria strain of the species Enterococcus faecium;
- wherein the Enterococcus faecium bacteria strain is the sole bacteria strain present in the pharmaceutical composition in an amount that is greater than 1×108 CFU/g with respect to a total weight of the pharmaceutical composition;
- wherein the Enterococcus faecium bacteria strain is live and lyophilized;
- and wherein the Enterococcus faecium bacteria strain has an enzyme profile as determined by a Rapid ID 32A analysis that is:
- (i) positive for at least one of:
- arginine dihydrolase, β-glucosidase, mannose fermentation, glutamic acid decarboxylase, arginine arylamidase, phenylalanine arylamidase, leucine arylamidase, pyroglutamic acid arylamidase, tyrosine arylamidase, glycine arylamidase, histidine arylamidase and serine arylamidase;
- and
- (ii) intermediate for N-acetyl-β-glucosaminidase.
4 more elements
Dependencies are inferred from the claim text.