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US 10,471,094 B2Granted
Methods for reducing ischemia-reperfusion injury via targeted control of blood gases
AssigneeCedars-Sinai Medical Center
InventorRohan Dharmakumar
Life of this patent
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Abstract
Provided herein are methods for reducing ischemia-reperfusion injury and/or microvascular obstructions by administering to the subject effective amounts of carbon dioxide and oxygen before, during and/or after re-establishing perfusion. In some embodiments, the methods further include using therapeutic hypothermia.
Claims20
A method for reducing or inhibiting ischemia-reperfusion injury in a subject in need thereof comprising:
- (i) administering to the subject a first admixture comprising carbon dioxide in an amount to reach a predetermined partial pressure of carbon dioxide to induce hyperemia;
- (ii) administering to the subject a second admixture comprising oxygen in an amount to reach a predetermined partial pressure of oxygen;
- (iii) administering oxygen in a block-wise manner to the subject prior to re-establishing perfusion so as to adapt the subject for reperfusion, wherein administering oxygen in a block-wise manner comprises alternating the amounts of oxygen administered between any of 5 mmHg and 100 mgHg, 20 mmHg and 100 mmHg, 30 mmHg and 100 mmHg, 40 mmHg and 100 mmHg, 50 mmHg and 100 mmHg, 60 mmHg and 100 mmHg, 70 mmHg and 100 mmHg, 80 mmHg and 100 mmHg, 90 mmHg and 100 mmHg, 20 mmHg and 40 mmHg, 30 mmHg and 40 mmHg, 20 mmHg and 50 mmHg, 30 mmHg and 50 mmHg, 40 mmHg and 50 mmHg, 20 mmHg and 60 mmHg, 30 mmHg and 60 mmHg, 40 mmHg and 60 mmHg, or 50 mmHg and 60 mmHg of oxygen;
- and
- (iv)re-establishing perfusion to an ischemic area, so as to reduce or inhibit ischemia-reperfusion injury in the subject.
2 more elements
A method for reducing microvascular obstructions in a subject in need thereof comprising:
- (i) administering to the subject a first admixture comprising carbon dioxide in an amount to reach a predetermined partial pressure of carbon dioxide to induce hyperemia;
- (ii) administering to the subject a second admixture comprising oxygen in an amount to reach a predetermined partial pressure of oxygen;
- (iii) administering oxygen in a block-wise manner to the subject prior to re-establishing perfusion so as to adapt the subject for reperfusion, wherein administering oxygen in a block-wise manner comprises alternating the amounts of oxygen administered between any of 5 mmHg and 100 mgHg, 20 mmHg and 100 mmHg, 30 mmHg and 100 mmHg, 40 mmHg and 100 mmHg, 50 mmHg and 100 mmHg, 60 mmHg and 100 mmHg, 70 mmHg and 100 mmHg, 80 mmHg and 100 mmHg, 90 mmHg and 100 mmHg, 20 mmHg and 40 mmHg, 30 mmHg and 40 mmHg, 20 mmHg and 50 mmHg, 30 mmHg and 50 mmHg, 40 mmHg and 50 mmHg, 20 mmHg and 60 mmHg, 30 mmHg and 60 mmHg, 40 mmHg and 60 mmHg, or 50 mmHg and 60 mmHg of oxygen;
- and
- (iv)re-establishing perfusion to an ischemic area, so as to reduce microvascular obstructions in the subject.
2 more elements
A method for reducing hemorrhagic microvascular obstructions in a subject in need thereof comprising:
- (i) administering to the subject a first admixture comprising carbon dioxide in an amount to reach a predetermined partial pressure of carbon dioxide to induce hyperemia;
- (ii) administering to the subject a second admixture comprising oxygen in an amount to reach a predetermined partial pressure of oxygen;
- (iii) administering oxygen in a block-wise manner to the subject prior to re-establishing perfusion so as to adapt the subject for reperfusion, wherein administering oxygen in a block-wise manner comprises alternating the amounts of oxygen administered between any of 5 mmHg and 100 mgHg, 20 mmHg and 100 mmHg, 30 mmHg and 100 mmHg, 40 mmHg and 100 mmHg, 50 mmHg and 100 mmHg, 60 mmHg and 100 mmHg, 70 mmHg and 100 mmHg, 80 mmHg and 100 mmHg, 90 mmHg and 100 mmHg, 20 mmHg and 40 mmHg, 30 mmHg and 40 mmHg, 20 mmHg and 50 mmHg, 30 mmHg and 50 mmHg, 40 mmHg and 50 mmHg, 20 mmHg and 60 mmHg, 30 mmHg and 60 mmHg, 40 mmHg and 60 mmHg, or 50 mmHg and 60 mmHg of oxygen;
- and
- (iv)re-establishing perfusion to an ischemic area, so as to reduce hemorrhagic microvascular obstructions in the subject.
2 more elements
Dependencies are inferred from the claim text.