Heparan sulphates for use in repair and/or regeneration of skin
AssigneeAgency for Science, Technology and Research
InventorsSimon Cool, Victor Nurcombe
Life of this patent
Estimating the term…
Abstract
Affinity purification of fibroblast growth factor 2-binding heparan sulphate from porcine mucosa (HS8) is disclosed. Also disclosed is the use of HS8 in repair and regeneration of the skin for treating wounds, burns, ulcers and other skin injuries.
Claims20
A method of healing a skin wound comprising contacting the skin wound with an effective amount of a pharmaceutical composition comprising heparan sulphate HS8, wherein the heparan sulphate HS8 is capable of specific binding to a peptide or polypeptide consisting of the amino acid sequence YCKNGGF (SEQ ID NO:2) and optionally 1 to 20 additional amino acids at one or both ends of the amino acid sequence SEQ ID NO:2, thereby promoting growth of skin cells.
A method of treating a subject having a skin wound, the method comprising administration of a therapeutically effective amount of heparan sulphate HS8 to the subject leading to repair and/or regeneration of skin at the wound, wherein the heparan sulphate HS8 is capable of binding a peptide or polypeptide consisting of the amino acid sequence YCKNGGF (SEQ ID NO:2) and optionally 1 to 20 additional amino acids at one or both ends of the amino acid sequence SEQ ID NO:2.
A method of skin grafting, skin reconstruction, or skin plastic surgery comprising contacting skin at or adjacent the region of grafting, reconstruction or plastic surgery with an effective amount of a pharmaceutical composition comprising heparan sulphate HS8, wherein the heparan sulphate HS8 is capable of specific binding to a peptide or polypeptide consisting of the amino acid sequence YCKNGGF (SEQ ID NO:2) and optionally 1 to 20 additional amino acids at one or both ends of the amino acid sequence SEQ ID NO:2, thereby promoting growth of skin cells.
Dependencies are inferred from the claim text.