Flavivirus protease inhibitors
AssigneeGeorgetown University
InventorsRadhakrishnan Padmanabhan, Tadahisa Teramoto, Mark Manzano
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Abstract
Methods of treating or preventing a Flavivirus infection in a subject are provided. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus protease inhibitor. These methods are useful in treating and/or preventing Flavivirus infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus. Methods of inhibiting a Flavivirus protease in a cell are also provided.
Claims14
A method of treating a Flavivirus infection in a subject, comprising administering to the subject a therapeutically effective amount of a compound selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof,
- wherein the compound inhibits a Flavivirus protease.
A method of inhibiting a Flavivirus protease in a cell, comprising:
- contacting a cell with an effective amount of a compound selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.