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US 10,471,079 B2Granted
Combination of selected analgesics and COX-II inhibitors
AssigneeGruenenthal GmbH
InventorsKlaus Schiene, Guenter Haase, Babette-Yvonne Koegel, Elmar Friderichs, Ulrich Jahnel
Life of this patent
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Abstract
Combinations of certain analgesics with COX-II inhibitors, related pharmaceutical compositions, including advantageous galenical forms containing these combinations, and the use of such combinations in methods of treatment, in particular for the treatment of pain.
Claims26
An active ingredient combination comprising:
- at least one analgesic compound selected from the group consisting of:
- (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol;
- and salts of the foregoing with a physiologically tolerated acid;
- and
- at least one COX-II inhibitor.
2 more elements
An active ingredient combination comprising:
- at least one analgesic compound selected from the group consisting of:
- (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol and salts of the foregoing with a physiologically tolerated acid;
- and
- at least one COX-II inhibitor selected from the group consisting of selected from the group consisting of celecoxib, rofecoxib, etoricoxib, valdecoxib, parecoxib, etodolac and nimesulide.
1 more element
An active ingredient combination comprising:
- at least one analgesic compound selected from the group consisting of:
- (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol;
- and salts of the foregoing with a physiologically tolerated acid;
- and
- at least one COX-II inhibitor selected from the group consisting of:
- celecoxib, rofecoxib, etoricoxib, valdecoxib, and parecoxib.
3 more elements
Dependencies are inferred from the claim text.