Compositions and methods to treat vision disorders

A method to treat a vision disorder in a subject in need thereof, said method comprises administrating to at least one eye of the subject a composition comprising a pharmaceutically acceptable ophthalmic carrier and a pharmaceutically effective amount of lanosterol, wherein said composition is administered topically, subconjunctivally, retrobulbarly, periocularly, subretinally, suprachoroidally, or intraocularly, wherein said composition is formulated as an ophthalmic solution, an ophthalmic gel, an ophthalmic ointment, an ophthalmic wash, an intraocular infusion solution, a wash for anterior chamber, or preservative for extracted cornea;

• wherein said lanosterol dissolves crystallin protein aggregate in the at least one eye of said subject;
• and wherein said vision disorder is selected from the group consisting of cataract, congenital cataracts, cortical opacities, posterior subcapsular cataract, presbyopia nuclear sclerosis, retinal degenerative disorder, Refsum disease, Smith-Lemli-Opitz syndrome, Schnyder crystalline corneal dystrophy, drusen, age-related macular degeneration, and diabetic retinopathy.