Back to results
US 10,471,075 B1Granted
Methods of reducing risk of preterm birth
AssigneeAMAG Pharmaceuticals, Inc.
InventorsRobert Birch, Michael J. Jozwiakowski
Life of this patent
Estimating the term…
Abstract
This disclosure generally relates to methods for reducing the risk of preterm birth in a pregnant human female patient that include subcutaneous administration of HPC. The disclosure relates in part to the discovery that subcutaneous administration of HPC is actually feasible and can result in sufficient plasma levels of HPC in pregnant patients that can reduce the risk of preterm birth.
Claims9
A method of reducing the risk of preterm birth in a pregnant human patient, comprising:
- subcutaneously administering to the posterior portion of the upper arm of the pregnant human patient a 1.1 mL dose comprising a pharmaceutically acceptable viscous non-aqueous liquid formulation comprising 275 mg 17-α hydroxyprogesterone caproate, castor oil, and benzyl benzoate,
- wherein the dose is subcutaneously administered weekly, beginning about 16 weeks or later of gestation.
A method of reducing the risk of preterm birth in a pregnant human patient, comprising:
- subcutaneously administering to the posterior portion of the upper arm of the pregnant human patient 1.1 mL of a dose comprising a pharmaceutically acceptable non-aqueous liquid formulation comprising 275 mg 17-α hydroxyprogesterone caproate, castor oil, and benzyl benzoate, and
- wherein the dose is subcutaneously administered once weekly, beginning between about 16 weeks, zero days of gestation to about 20 weeks, six days of gestation, and continued until about 37 weeks of gestation or until delivery, whichever occurs first, and
- wherein the pregnant human patient has a singleton pregnancy and a history of singleton spontaneous preterm birth.
Dependencies are inferred from the claim text.