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US 10,471,072 B2Granted
Vaginal inserted estradiol pharmaceutical compositions and methods
AssigneeTherapeuticsMD, Inc.
InventorsBrian A. Bernick, Peter H. R. Persicaner, Janice Louise Cacace, Neda Irani, Julia M. Amadio
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Abstract
In one aspect, pharmaceutical compositions and methods for the treatment of vulvovaginal atrophy (VVA) are provided. In one embodiment, the method comprises digitally inserting into the lower third of the vagina of a subject having VVA a soft gelatin capsule containing a liquid pharmaceutical composition.
Claims7
A method for treating moderate to severe dyspareunia in a human subject, the method comprising:
- inserting about two inches into the vagina of the subject a soft gelatin capsule containing a liquid pharmaceutical composition, wherein the composition comprises about 4 μg to about 25 μg of estradiol and an excipient that increases the viscosity of the composition, wherein the composition has a viscosity from about 50 cP to about 1000 cP at 25° C., and wherein the composition spreads over the vaginal tissue and the estradiol is absorbed by the vaginal tissue.
Dependencies are inferred from the claim text.