Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis
AssigneeAdare Pharmaceuticals, Inc.
InventorsMichael A. Gosselin, Jin-Wang Lai, Gopi M. Venkatesh
Life of this patent
Estimating the term…
Abstract
The present invention is directed to orally administered compositions of topically acting corticosteroids for the treatment of inflammation of the gastrointestinal tracts such as eosinophilic esophagitis. The present invention also provides a method for treating conditions associated with inflammation of the gastrointestinal tract in an individual. The method comprises administering to an individual in need thereof a pharmaceutical composition of the present invention as orally disintegrating tablets comprising a topically active corticosteroid adsorbed onto a pharmaceutically acceptable carrier such as silicified microcrystalline cellulose.
Claims40
A pharmaceutical composition in the form of an orally disintegrating tablet comprising:
- a. a topically acting corticosteroid or pharmaceutically acceptable salt, ester, or polymorph adsorbed onto a pharmaceutically acceptable carrier;
- and
- b. rapidly dispersing microgranules comprising a sugar alcohol, or a saccharide, or a mixture thereof and at least one disintegrant, wherein the sugar alcohol or saccharide and the disintegrant are present in a ratio of sugar alcohol or saccharide to disintegrant of from 90:10 to 99:1
- wherein the corticosteroid is present in an amount of about 5% or less by weight in the composition.
Dependencies are inferred from the claim text.