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US 10,471,070 B2Granted
Methods for delivering a bio-active agent or bio-active agents to an eye of a mammal
OwnerEyal Sheetrit, Izhar Halahmi +1inventors
InventorsEyal Sheetrit, Izhar Halahmi, Ishay Attar
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Abstract
In some embodiments, the present invention is a composition, including: a bulking agent, where the bulking agent is a kaolin, an absorbent material, where the absorbent material is a fumed silica, a binder, where the binder is an epoxy, and a first active agent, where the first active agent is Latanoprost.
Claims8
A method, comprising:
- administering a composition in a form of a punctal plug to an eye of a mammal in need thereof,
- wherein the composition releases from 0.5-10 micrograms of a first active agent per day, and
- wherein the composition comprises:
- a bulking agent comprising a kaolin,
- an absorbent material comprising a fumed silica,
- a binder comprising an epoxy, and
- the first active agent comprises Latanoprost;
- wherein the bulking agent is present in an amount ranging from 20-30% by weight (w/w) of the total weight of the composition;
- wherein the absorbent material is present in an amount ranging from 10-20% by weight (w/w) of the total weight of the composition;
- wherein the binder is present in an amount ranging from 15-35% by weight (w/w) of the total weight of the composition;
- wherein the first active agent is present in an amount ranging from 5-40% by weight (w/w) of the total weight of the composition;
- and
- wherein the bulking agent, the absorbent material, the binder, and the first active agent are present in a composite.
10 more elements
Dependencies are inferred from the claim text.