Phenoxy acetic acids and phenyl propionic acids as PPAR delta agonists
AssigneevTv Therapeutics LLC
InventorsPer Sauerberg, Pavel Pihera, Zdenek Polivka, Miroslav Havranek, Ingrid Pettersson, John Patrick Mogensen
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Abstract
Phenoxy acetic acids and phenyl propionic acids and their use in improving mitochondrial energy output in a subject are provided herein. The present compounds are activators of PPARδ and may be useful for treating conditions mediated by the same.
Claims10
A method of improving mitochondrial energy output in a subject, the method comprising administering to a subject in need thereof an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof:
- wherein is a double bond, with either E or Z substitution;
- X1 is C1-6 alkyl substituted with morpholino;
- X2 is phenylene;
- X3 is phenyl substituted with one or more halogens;
- Ar is phenylene optionally substituted with methyl;
- Y1 is O;
- Y2 is CH2;
- Z is CH2;
- R1 is hydrogen;
- and
- R2 is hydrogen.
A method of improving mitochondrial energy output in a subject, the method comprising administering to a subject in need thereof an effective amount of a compound of selected from the group consisting of:
- (Z)-[2-Methyl-4-[3-(4-methylphenyl)-3-[4-[3-(morpholin-4-yl)propynyl]phenyl]allyloxy]-phenoxy]acetic acid;
- (E)-[2-Methyl-4-[3-[4-[3-(pyrazol-1-yl)prop-1-ynyl]phenyl]-3-(4-trifluoromethylphenyl)-allyloxy]phenoxy]acetic acid;
- (E)-[2-Methyl-4-[3-[4-[3-(morpholin-4-yl)propynyl]phenyl]-3-(4-trifluoromethylphenyl) allyloxy]-phenoxy]acetic acid;
- (E)-[2-Methyl-4-[3-(4-methylphenyl)-3-[4-[3-(morpholin-4-yl)propynyl]phenyl]allyloxy]-phenoxy]acetic acid;
- and
- (Z)-[2-Methyl-4-[3-[4-[3-(morpholin-4-yl)propynyl]phenyl]-3-(4-trifluoromethylphenyl) allyloxy]-phenoxy]acetic acid;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.