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US 10,471,034 B2Granted
Amino acid compositions and methods for the treatment of liver diseases
AssigneeAxcella Health Inc.
InventorsMichael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt
Life of this patent
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Abstract
This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
Claims20
A composition comprising:
- (a)
- L-leucine or a salt thereof, or a dipeptide or salt thereof, or tripeptide or salt thereof, comprising L-leucine;
- (b) an arginine amino acid entity chosen from:
- (i) L-arginine or a salt thereof,
- (ii) a dipeptide or salt thereof, or tripeptide or salt thereof, comprising L-arginine,
- (iii) ornithine or a salt thereof,
- (iv) a dipeptide or salt thereof, or tripeptide or salt thereof, comprising ornithine,
- (v) creatine or a salt thereof, or
- (vi) a dipeptide or salt thereof, or tripeptide or salt thereof, comprising creatine;
- (c) L-glutamine or a salt thereof or a dipeptide or salt thereof, or tripeptide or salt thereof, comprising L-glutamine;
- and
- (d) N-acetylcysteine (NAC) or a salt thereof or a dipeptide or salt thereof, or tripeptide or salt thereof, comprising NAC;
- wherein when the composition is in powder form, at least 50 wt. % of the total wt. of the composition is one or more amino acid entities in free form, and wherein the total wt. % of (a)-(d) is greater than the total wt. % of other amino acid entities in the composition.
10 more elements
A pharmaceutical composition consisting essentially of:
- (a) L-leucine or a salt thereof;
- (b) L-arginine or a salt thereof;
- (c) L-glutamine or a salt thereof;
- (d) NAC or a salt thereof;
- (e) L-isoleucine or a salt thereof;
- (f) L-valine or a salt thereof;
- and
- (g) one or more pharmaceutically acceptable excipients.
5 more elements
Dependencies are inferred from the claim text.