Bioresorbable nonlamellar microparticles and uses thereof
AssigneeCentre National de la Recherche Scientifique (CNRS)
InventorsYasemin Ataman-Onal, Thierry Delair, Genevieve Inchauspe, Pascale Jeannin, Glaucia Paranhos-Baccala, Bernard Verrier
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Abstract
Nonlamellar bioresorbable microparticles to which protein substances are bonded, and a method for preparing the microparticles, comprising: (i) preparing the microparticles from at least one bioresorbable polymer without stabilizer and without surfactant; and (ii) bonding the protein substances to the microparticles obtained in step (i) without surfactant.
Claims8
Bioresorbable nonlamellar microparticles to which protein substances are bonded, consisting of poly(lactic acid),
- the microparticles being obtained by:
- (i) preparing, without stabilizer and without surfactant, said microparticles by a solvent displacement method;
- and
- (ii) bonding said protein substances to the microparticles obtained in step (i) without surfactant;
- wherein the microparticles to which are bonded the protein substances exhibit colloidal stability, and have a diameter in a range of 150 to 250 nm.
Bioresorbable nonlamellar microparticles to which protein substances are bonded, comprising poly(lactic acid),
- wherein the microparticles exhibit colloidal stability, are devoid of stabilizer and surfactant, and have a diameter in a range of 150 to 250 nm.
Dependencies are inferred from the claim text.