Optimized nucleic acid sequences coding for the alpha-chain of human chorionic gonadotropin
AssigneeFerring B.V.
InventorsDaniel Plaksin, Ayelet Grinhut
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Abstract
A host cell characterized in that it comprises integrated into its genome a sequence coding for the a chain of hCG, and use of the host cell to produce recombinant hCG.
Claims17
A polynucleotide sequence comprising an optimized hCG α-chain nucleic acid sequence selected from SEQ ID NO:1 and sequences having at least 97% sequence identity thereto, and SEQ ID NO:4 and sequences having at least 97% sequence identity thereto.
A cultured transformed cell having integrated into its genome an optimized hCG α-chain polynucleotide sequence comprising SEQ ID NO:1 or a sequence having at least 96.5% sequence identity thereto or SEQ ID NO:4 or a sequence having at least 96.5% sequence identity thereto.
Dependencies are inferred from the claim text.