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US 10,464,968 B2Granted
Method for producing a composition for treating a tooth lesion
AssigneeCredentis AG
InventorsMichael Hug, Dominikus Amadeus Lysek
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Abstract
The invention relates to a method for preparing a composition for treating a tooth lesion, said composition comprising peptides that are capable of undergoing self-assembly at a certain pH. The compositions of the invention are highly suitable for being used in the medical field, in particular for remineralising a tooth lesion such as a subsurface caries lesion.
Claims7
A composition in lyophilized undissolved form comprising
- a peptide that undergoes self-assembly at a pH value below 7.5, wherein the peptide is predominantly in a monomeric form;
- a non-reducing sugar;
- and
- a non-volatile buffer;
- wherein upon reconstitution of the composition in water, a solution with an ionic strength of less than 0.15 and a pH that is 0.1 to 0.5 pH units above the pH at which the peptide starts to undergo self-assembly is obtained in which the peptide is predominantly present in a monomeric form.
2 more elements
Dependencies are inferred from the claim text.