Substituted nucleosides, nucleotides and analogs thereof

A compound of Formula (I), or a pharmaceutically acceptable salt thereof:

• wherein:
• B1A is an optionally substituted purine base or an optionally substituted pyrimidine base;
• R1A is selected from the group consisting of hydrogen, an optionally substituted acyl, an optionally substituted O-linked amino acid,
• the dashed line (------) is absent;
• R2A is selected from the group consisting of an unsubstituted C1-6 alkyl, a halogen-substituted C1-6 alkyl, a hydroxy-substituted C1-6 alkyl, an alkoxy-substituted C1-6 alkyl and a sulfenyl-substituted C1-6 alkyl;
• R3A is selected from the group consisting of OH, OC(═O)R″A and an optionally substituted O-linked amino acid;
• R4A is fluoro;
• R5A is hydrogen;
• R6A and R7A are each absent or independently selected from the group consisting of hydrogen, an optionally substituted C1-24 alkyl, an optionally substituted C2-24 alkenyl, an optionally substituted C2-24 alkynyl, an optionally substituted C3-6 cycloalkyl, an optionally substituted C3-6 cycloalkenyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aryl(C1-6 alkyl), an optionally substituted *—(CR15AR16A)p—O—C1-24 alkyl, an optionally substituted *—(CR17AR18A)q—O—C1-24 alkenyl,
• R6A is
• and R7A is absent or hydrogen;
• or
• R6A and R7A are taken together to form a moiety selected from the group consisting of an optionally substituted
• and an optionally substituted
• wherein the oxygens connected to R6A and R7A, the phosphorus and the moiety form a six-membered to ten-membered ring system;
• R8A is selected from the group consisting of absent, hydrogen, an optionally substituted aryl and an optionally substituted heteroaryl;
• R9A is selected from the group consisting of NR30AR31A, an optionally substituted N-linked amino acid and an optionally substituted N-linked amino acid ester derivative;
• R10A and R11A are independently an optionally substituted N-linked amino acid or an optionally substituted N-linked amino acid ester derivative;
• R12A, R13A and R14A are each independently absent or hydrogen;
• each R15A, each R16A, each R17A and each R18A are each independently selected from the group consisting of hydrogen, an optionally substituted C1-24 alkyl and alkoxy;
• R22A and R23A are each independently selected from the group consisting of hydrogen, an optionally substituted C1-24 alkyl and an optionally substituted aryl;
• R24A is selected from the group consisting of hydrogen, an optionally substituted C1-24 alkyl, an optionally substituted aryl, an optionally substituted —O—C1-24 alkyl and an optionally substituted —O-aryl;
• R25A and R29A are each independently selected from the group consisting of hydrogen, an optionally substituted C1-24 alkyl and an optionally substituted aryl;
• R″A is an optionally substituted C1-24-alkyl;
• m is 0 or 1;
• p and q are each independently selected from the group consisting of 1, 2 and 3;
• and
• Z1A, Z2A, Z3A, Z4A are each O.