# US 10,464,902 B1 · Multi-tyrosine kinase inhibitors derivatives and methods of use

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- Number: US 10,464,902 B1
- Document ID: US10464902B1
- Status: Granted
- Kind: B1
- Application number: 15/812,399
- Filed: 2017-11-14
- Granted: 2019-11-05
- Earliest claimed: 2015-06-29
- Assignees: Ontogenesis, LLC
- Applicants: Ontogenesis, LLC
- Inventors: Gerald Horn
- Web page: https://patentgrep.com/patent/US10464902B1

## CPC

- C07D 215/22: attached in position 2 or 4
- C07D 215/48: Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D 413/12: linked by a chain containing hetero atoms as chain links
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

The present invention is directed to multi-tyrosine kinase inhibitor compounds. The present invention is further directed to compositions comprising those compounds. Finally, the present invention is directed to methods of treating eye conditions including, but not limited to, diabetic background retinopathy, diabetic macular edema, diabetic proliferative retinopathy, diabetic macular edema with proliferative retinopathy, proliferative fibrovascular disease, diabetic macular edema with proliferative fibrovascular disease, retinopathy of prematurity, dry macular degeneration, dry macular degeneration with drusen and wet macular degeneration, using compounds and compositions of the invention.

## Claims

### Claim 1

A compound selected from
wherein X is a peptide, a protein or absent.

### Claim 2 (depends on 1)

A composition comprising a compound of claim 1 and one or more pharmaceutically acceptable excipients.