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US 10,464,889 B2Granted
Sulfonylaminobenzamide compounds as anthelmintics
AssigneeElanco Tiergesundheit AG
InventorsNoelle Gauvry, Chouaib Tahtaoui
Life of this patent
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Abstract
The present invention relates to a new compound of formula (I) wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt thereof. The compounds of formula (I) are useful in the control of parasites, in particular endoparasites, in and on vertebrates.
Claims8
A compound of formula
- or a salt or an enantiomer thereof, wherein
- n is 0 or 1;
- A is C3-C6-cycloalkyl;
- C3-C6-halocycloalkyl;
- 5- or 6-membered heterocycloalkyl having from 1 to 3 same or different heteroatoms selected from the group consisting of B, N, O and S, which is further unsubstituted or substituted by halogen, C1-C4-alkyl or C1-C4-alkoxy;
- or is cinnamyl, which is unsubstituted or substituted in the phenyl moiety by halogen, C1-C4-alkyl or C1-C4-alkoxy;
- or is a heteroaromatic radical, which is further unsubstituted or substituted by halogen, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C2-C4-alkanoyl, 5- or 6-membered heterocycloalkyl-C1-C2-alkyl or unsubstituted or halogen-, C1-C4-alkyl- or C1-C4-alkoxy-substituted phenyl;
- or is a hetero-bicyclic ring radical comprising a total of 8 to 10 ring members, from which 1 to 5 members are same or different heteroatoms selected from the group consisting of B, N, O and S, and from which 0 to 2 members are a group C(O)—, which bicyclic ring radical is further unsubstituted or substituted by halogen, cyano, hydroxyl, C1-C4-alkyl or C1-C4-haloalkyl;
- R2 is H or S(O2)-T;
- T is C1-C6-alkyl which is unsubstituted or substituted by halogen, trimethylsilyl, C3-C6-cycloalkyl, carboxyl or C1-C4-alkoxycarbonyl;
- C3-C6-cycloalkyl;
- C6-C12-bicarbocyclyl;
- a 5- or 6 membered heteroaromatic radical, which is further unsubstituted or substituted by halogen, cyano, nitro, C1-C4-alkyl, C1-C4-haloalkyl or C1-C4-alkoxy;
- 5- or 6-membered heterocycloalkyl having from 1 to 3 same or different heteroatoms selected from the group consisting of N, O, S and S(O2), which is further unsubstituted or substituted by C1-C4-alkyl, C1-C2-alkoxycarbonyl or benzyloxycarbonyl;
- a group
- amino;
- or N-mono- or N,N-di-C1-C4-alkylamino;
- R3 is C1-C4-alkyl, unsubstituted or halogen-, C1-C4-alkyl- or C1-C4-haloalkyl-substituted phenyl, unsubstituted or halogen-, C1-C4-alkyl- or C1-C4-haloalkyl-substituted pyridyl, C1-C4-alkoxycarbonyl-methyl or morpholin-4-yl-carbonylmethyl;
- R0 is H or hydroxy;
- and
- Y is
- (i) phenyl or a phenylamino, which is substituted by one or more same or different radicals selected from the group consisting of halogen;
- C1-C6-alkyl;
- C1-C6-haloalkyl;
- C3-C6-cycloalkyl;
- C3-C6-halocycloalkyl;
- hydroxyl;
- C1-C6-alkoxy;
- C1-C6-haloalkoxy;
- C1-C6-alkylthio;
- C1-C6-haloalkylthio;
- C1-C6-alkyl-sulfinyl;
- C1-C6-haloalkylsulfinyl;
- C1-C6-alkylsulfonyl;
- C1-C6-haloalkylsulfonyl;
- SF5;
- amino;
- N-mono- or N,N-di-C1-C6-alkylamino;
- tri-C1-C4-alkylsilyl;
- C1-C6-alkoxycarbonyl;
- aminocarbonyl;
- N-mono- or N,N-di-C1-C6-alkylaminocarbonyl;
- aminosulfonyl;
- N-mono- or N,N-di-C1-C6-alkylaminosulfonyl;
- N—C1-C6-alkylsulfonylamino;
- C1-C6-alkoxycarbonylamino;
- N—C1-C4-alkyl-N—C1-C6-alkoxycarbonylamino;
- cyano;
- nitro;
- and halogen-, C1-C4-alkyl-, C1-C4-haloalkyl-, C1-C4-alkoxy-, C1-C4-haloalkoxy-, amino-, cyano- or nitro-substituted C3-C6-heterocyclyl;
- or is
- (ii) 5- or 6 membered heteroaryl or heteroarylamino, which is each further unsubstituted or substituted by halogen, cyano, nitro, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-alkoxycarbonyl, C2-C4-alkanoyl, or phenyl or phenylsulfonyl which is each unsubstituted or substituted by halogen, cyano, nitro, methyl or methoxy;
- or is
- (iii) benzoyl or 5- or 6 membered heteroarylcarbonyl, which is each further unsubstituted or substituted by halogen, cyano, nitro, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-alkoxycarbonyl, C2-C4-alkanoyl or phenyl;
- or is
- (iv) a C6-C12-bicarbocyclic radical;
- or is a
- (v) a radical —H2C—C(O)—NH—R4, wherein R4 is C1-C4-haloalkyl, C2-C3-alkynyl or cyano-C1-C4-alkyl;
- or
- R0 and Y together with the N-atom to which they are attached, form a piperidinyl or piperazinyl radical which is substituted by C1-C4-alkyl, C1-C4-alkoxy, unsubstituted or halogen-, C1-C4-alkyl-, C1-C4-haloalkyl-, amino- and/or C1-C4-alkoxy-substituted phenyl or benzoylamino, or unsubstituted or C1-C4-alkyl-, C1-C4-haloalkyl-, C3-C6-cycloalkyl- or halogen-substituted pyridyl or pyrimidinyl.
57 more elements
Dependencies are inferred from the claim text.