Anthelmintic compounds
AssigneeBoehringer Ingelheim Animal Health USA Inc.
InventorsAlan Long, Srinivas Reddy Gurrala
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X6, X8, Q1, Q2, Q3, Q4, Q5, Q6, Ring A, Ring B, W, W′, R2, R3, R, R′, m, n and q are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.
Claims20
An anthelmintic compound of formula (IA-1):
- wherein:
- Y is naphthyl, benzofuranyl, dihydrobenzofuranyl, quinolinyl, isoquinolinyl, tetrahydroquinolyl, tetrahydroisoquinolyl, indolyl, isoindolyl, benzothiophenyl, benzimidazolyl, benzoxazolyl or benzothiazolyl, which is optionally substituted by one or more of chloro, fluoro, bromo, CF3, OCF3, SCF3 or SF5;
- Z is phenyl optionally substituted by one or more halogen, cyano, nitro, CF3, SF5, S(O)C1-3-alkyl, S(O)2—C1-3-alkyl, S(O)C1-3-haloalkyl or S(O)2C1-3-haloalkyl;
- X1 is a bond, —C(O)—, —(CH2)— where n is 1 to 3 or —NH—, wherein each CH2 in —(CH2)n and —NH— is optionally independently substituted with one or two substituents selected from the group consisting of halogen, C1-3alkyl, C1-3haloalkyl, hydroxy-C1-3alkyl, C1-3alkoxy-C1-3alkyl, amino-C1-3alkyl, C1-3alkylamino-C1-3alkyl, C1-3dialkylamino-C1-3alkyl, C1-3alkoxycarbonyl, C1-3alkylcarbonyl and C2-4alkenylcarbonyl, each of which may be further independently substituted by hydroxy, hydroxy-C1-3alkyl, amino, C1-3alkylamino, C1-3dialkylamino or —COOH;
- Ring A is L1, L2, L3, L13, L14, L15, L16, L17 or L18 wherein Q5 and Q6 are nitrogen;
- R5, R6, R7 and R8 are independently hydrogen, C1-3alkyl or C1-3haloalkyl:
- Ring B is L4 wherein Q1 is carbon and Q2 is nitrogen:
- W is O;
- X6 is a bond, —O—, —(CH2)— where n is 1 to 3 or —NH—;
- X8 is a bond, —(CH2)n— where n is 1 to 3, —O— or —NH—, wherein each CH2 in —(CH2)n— and —NH— is optionally independently substituted with one or two substituents selected from the group consisting of halogen, C1-3alkyl, C1-3haloalkyl, hydroxy-C1-3alkyl, C1-3alkoxy-C1-3alkyl, amino-C1-3alkyl, C1-3alkylamino-C1-3alkyl, C1-3dialkylamino-C1-3alkyl, C1-3alkoxycarbonyl, C1-3alkylcarbonyl and C2-4alkenylcarbonyl, each of which may be further independently substituted by hydroxy, hydroxy-C1-3alkyl, amino, C1-3alkylamino, C1-3dialkylamino or —COOH;
- R2 and R3 are H;
- n is 1 or 2;
- and
- m and q are 0.
Dependencies are inferred from the claim text.