Uses of sesquiterpene lactone compounds and their derivatives in drugs preparation

A method of treating rheumatoid arthritis in a patient comprising administering a therapeutically effective amount of compound of formula I

• Formula (I) t o a patient in need of rheumatoid arthritis treatment wherein the compounds of Formula I are selected from the group consisting of
• and wherein the compound of formula (I) are formulated in the form of injections, tablet, or capsule and administered in a therapeutically effective amount to reduce a content of TNF-α, PGE2 and IL-1β.