Microneedle-based transdermal delivery system and method of making same
AssigneeThe Corporation of Mercer University
InventorMartin J. D'Souza
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Abstract
A transdermal delivery system of microneedles containing a bioactive material, comprising at least one layer of a support material; at least one biodegradable needle associated with the support material, each needle comprising at least one biodegradable polymer and at least one sugar, wherein each biodegradable needle is hollow and is adapted to retain a bioactive material.
Claims12
A transdermal delivery system, comprising:
- at least one biodegradable needle comprising
- i. at least one biodegradable polymer,
- ii. at least one sugar;
- and,
- iii. an encapsulated bioactive material,
- wherein the at least one biodegradable needle contains encapsulated bioactive material such that the bioactive material does not directly contact the at least one biodegradable polymer or the at least one sugar.
A transdermal delivery system, comprising:
- at least one biodegradable needle comprising
- i. at least one biodegradable polymer, wherein the biodegradable polymer is polydimethylsiloxane;
- ii. at least one sugar;
- and,
- iii. an encapsulated bioactive material,
- wherein the at least one biodegradable needle contains encapsulated bioactive material such that the bioactive material does not directly contact the at least one biodegradable polymer or the at least one sugar.
A transdermal delivery system, comprising:
- at least one biodegradable needle comprising
- i. at least one biodegradable polymer,
- ii. at least one sugar;
- and,
- iii. an encapsulated bioactive material,
- wherein the at least one biodegradable needle contains encapsulated bioactive material such that the bioactive material does not directly contact the at least one biodegradable polymer or the at least one sugar;
- and,
- wherein the bioactive material is at least one material provided in microencapsulated particle form.
A transdermal delivery system, comprising:
- at least one biodegradable needle comprising
- i. at least one biodegradable polymer;
- ii. at least one sugar;
- and,
- iii. an encapsulated bioactive material,
- wherein the at least one biodegradable needle contains encapsulated bioactive material such that the bioactive material does not directly contact the at least one biodegradable polymer or the at least one sugar;
- and,
- wherein the at least one biodegradable microneedle is able to degrade within 12 minutes after delivery to a subject's skin.
A transdermal delivery system, comprising:
- at least one biodegradable needle comprising
- i. at least one biodegradable polymer;
- ii. at least one sugar;
- and,
- iii. an encapsulated bioactive material,
- wherein the at least one biodegradable needle contains encapsulated bioactive material such that the bioactive material does not directly contact the at least one biodegradable polymer or the at least one sugar;
- and,
- wherein the bioactive material is in the form of microencapsulated material having an average particle size in a range of 0.01-50 μm.
A transdermal delivery system, comprising:
- at least one biodegradable needle comprising
- i. at least one biodegradable polymer;
- ii. at least one sugar;
- and,
- iii. an encapsulated bioactive material,
- wherein the at least one biodegradable needle contains encapsulated bioactive material such that the bioactive material does not directly contact the at least one biodegradable polymer or the at least one sugar;
- and,
- wherein the bioactive material is in the form of microencapsulated material having an average particle size in a range of 1-4 μm.
Dependencies are inferred from the claim text.