US 10,463,469 B2 · Artificial blood vessel, method for producing artificial blood vessel, and method for producing porous tissue regeneration substrate

Abstract

The present invention aims to provide a method for producing a porous tissue regeneration substrate that allows a wide choice of solvents and easy adjustment of the bulk density and pore size of the porous substrate. The present invention also aims to provide a method for producing an artificial blood vessel and an artificial blood vessel. The present invention relates a porous, tubular artificial blood vessel containing a bioabsorbable material, the artificial blood vessel including: a skin layer having a relatively small pore size as an innermost layer; and a porous layer positioned around the skin layer and having a relatively large pore size.

Claims5

Dependent claims

A method for producing a porous, tubular artificial blood vessel containing a bioabsorbable material, the method comprising:

a dissolving step of preparing a uniform solution containing a bioabsorbable polymer dissolved therein using a bioabsorbable polymer, a solvent 1 having a relatively low solvency for the bioabsorbable polymer, a solvent 2 having a relatively high solvency for the bioabsorbable polymer and being incompatible with the solvent 1, and a common solvent 3 compatible with the solvent 1 and the solvent 2;
an applying step of applying the uniform solution to a surface of a rod-shaped body;
a precipitating step of cooling the uniform solution on the surface of the rod-shaped body to precipitate a tubular porous body containing the bioabsorbable polymer around the rod-shaped body;
and
a freeze-drying step of freeze-drying the tubular porous body to give a tubular artificial blood vessel.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/747,815Filed 2 Aug 2016

Priority

JP 2015-1562046 Aug 2015

Published

US 2018/0221132 A19 Aug 2018

Granted

5 Nov 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

A61F 2/06
Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts: blood vessels
A61L 27/507
Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface…:…
A61L 27/56
Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface…:…
A61L 27/58
Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface…:…

Artificial blood vessel, method for producing artificial blood vessel, and method for producing porous tissue regeneration substrate

Life of this patent

Artificial blood vessel, method for producing artificial blood vessel, and method for producing porous tissue regeneration substrate

Life of this patent

Abstract

Claims5