Methods and compositions to treat liver diseases and conditions
AssigneeAsociacióN Centro De InvestigacióN Cooperativa En Biociencias-Cic Biogune
InventorsMaria Luz Martinez Chantar, Juan Anguita
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Abstract
Methods and compounds useful to treat diseases and conditions are provided. Methods of administering one or more microRNA-inhibitor compounds or one or more microRNA-enhancing compounds to cells, tissues, and/or subjects as a treatment for a disease or condition are provided.
Claims14
A method of increasing glycine N-methyltransferase (GNMT) enzyme activity in a cell, the method comprising contacting a cell with an miRNA-inhibitor compound that inhibits at least one of miRNA-873-5p and miRNA-518d-5p in an amount effective to increase GNMT enzyme activity in the cell, wherein the increase in GNMT enzyme activity reduces DNA hypermethylation in the cell.
Dependencies are inferred from the claim text.