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US 10,457,665 B2Granted
1,4-di-(4-methylthiophenyl)-3-phtaloylazetidine-2-one and the derivatives thereof
AssigneesUniversite De Nantes, Universite De Bourgogne, Institut National De La Sante Et De La Recherche Medicale (Inserm)
InventorsJean-Michel Robert, Stéphanie Troy-Fioramonti, Laurent Demizieux, Pascal DeGrace
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Abstract
The present invention relates to a compound with formula (I) or a salt and/or a pharmaceutically acceptable solvate thereof, the method for preparing same as well as the uses thereof, in particular the therapeutic use thereof, mainly in the treatment of diseases associated with a hyperactivity of the endocannabinoid system.
Claims17
A compound of following formula (I):
- wherein:
- R1 and R2, which can be identical or different, represent a hydrogen atom or a COR3, SO2R4 or CONR5R6 group;
- or form together with the nitrogen atom that bears them a 5- or 6-member heterocycle comprising at least one additional heteroatom, C═O group, aryl group or heteroaryl group;
- R3, R4, R5 and R6 independently represent a hydrogen atom, or an aryl or heteroaryl group, said group being optionally substituted by one or more groups selected from a halogen atom, OR7, NR8R9, SR10, S(O)R11, SO2R12, SO2NR13R14, OCOR15, NR16COR17, NR18C(O)OR19, CO2R20, CONR21R22, OCO2R23, OCONR24R25, COR26, nitro (NO2), cyano (CN), oxo (═O) and CF3;
- and
- R7 to R26 independently represent a hydrogen atom or a (C1-C6)alkyl, aryl or aryl-(C1-6)alkyl group,
- or a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.