Process for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds

A process for preparing a compound of Formula I:

• or a salt thereof, the process comprising:
• (a) cyclizing a compound of VIb:
• or a salt thereof to form a compound of Formula (V);
• wherein each X is hydroxyl;
• (b) brominating the compound of Formula V or a salt thereof with a brominating agent to form a compound of Formula IV:
• or a salt thereof, wherein Y is bromo;
• (c) contacting the compound of Formula IV with a piperazine compound having the structure:
• or a salt thereof, wherein Lv is a leaving group and R1 is an amino protecting group to form a compound of Formula III:
• or a salt thereof;
• and
• (d) contacting the compound of Formula III with a metalating agent to form the compound of Formula I, or a salt thereof;
• wherein R1 is hydrogen or an amino protecting group.