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US 10,450,588 B2Granted
Glycerol and acetic acid converting yeast cells with improved acetic acid conversion
AssigneeDsm IP Assets B.V.
InventorsPaul Klaassen, Antonius Willem Wouter Hartman
Life of this patent
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Abstract
Cell that is genetically modified comprising: a) one or more nucleotide sequence encoding a NAD+-dependent acetylating acetaldehyde dehydrogenase (E.C. 1.2.1.10); b) one or more nucleotide sequence encoding a acetyl-CoA synthetase (E.C. 6.2.1.1); c) one or more nucleotide sequence encoding a glycerol dehydrogenase (E.C. 1.1.1.6); and d) one or more nucleotide sequence encoding a dihydroxyacetone kinase (E.C. 2.7.1.28 or E.C. 2.7.1.29).
Claims5
A Saccharomyces cerevisiae cell that is genetically modified comprising:
- a) a recombinant nucleotide sequence encoding a NAD+-dependent acetylating acetaldehyde dehydrogenase (E.C. 1.2.1.10) of SEQ ID NO:
- 2;
- b) a recombinant nucleotide sequence encoding an acetyl-CoA synthetase (E.C. 6.2.1.1) of SEQ ID NO:
- 6;
- c) a recombinant nucleotide sequence encoding a glycerol dehydrogenase (E.C. 1.1.1.6) of SEQ ID NO:
- 7;
- and
- d) a recombinant nucleotide sequence encoding a dihydroxyacetone kinase (E.C. 2.7.1.28 or E.C. 2.7.1.29) of SEQ ID NO:
- 13;
- wherein
- wherein the recombinant nucleotide sequences are overexpressed in the yeast cell.
8 more elements
Dependencies are inferred from the claim text.