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US 10,450,585 B2Granted
Delivery methods and compositions for nuclease-mediated genome engineering
AssigneeSangamo Therapeutics, Inc.
InventorsGary K. Lee, Brigit E. Riley, Susan J. St. Martin, Thomas Wechsler
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Abstract
The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a cell.
Claims13
A method of introducing a donor nucleic acid molecule into an isolated cell, the method comprising:
- administering to the cell at least one adeno-associated virus (AAV) vector comprising a donor nucleic acid molecule in the presence of at least one inhibitor of Platelet-derived growth factor receptor under conditions sufficient to increase efficiency of viral delivery to the cell, wherein the AAV vector has an AAV6 capsid.
A method of introducing a donor nucleic acid molecule into an isolated cell, the method comprising:
- administering to the cell at least one adeno-associated virus (AAV) vector comprising a donor nucleic acid molecule in the presence of at least one inhibitor of Platelet-derived growth factor receptor under conditions sufficient to increase efficiency of viral delivery to the cell, wherein the inhibitor is selected from the group consisting of CP-673451 and Crenolanib and wherein the AAV vector has an AAV6 capsid.
Dependencies are inferred from the claim text.