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US 10,450,367 B2Granted
Human antibodies against rabies and uses thereof
AssigneeUniversity of Massachusetts
InventorsWilliam D. Thomas, Jr., Yang Wang
Life of this patent
Estimating the term…
Abstract
The invention provides human antibodies against rabies and methods of using the same.
Claims32
An antibody that specifically binds to rabies virus G protein, wherein the antibody comprises the following six complementarity determining regions (CDRs):
- (a) a CDR-H1 comprising the amino acid sequence of GFTFSYFAMH (SEQ ID NO:
- 1);
- (b) a CDR-H2 comprising the amino acid sequence of TIGTGGGTYYADSVKG (SEQ ID NO:
- 2);
- (c) a CDR-H3 comprising the amino acid sequence of CARDNALRSFDWLFYSFDY (SEQ ID NO:
- 3);
- (d) a CDR-L1 comprising the amino acid sequence of RASQSISSSYLA (SEQ ID NO:
- 4);
- (e) a CDR-L2 comprising the amino acid sequence of GASSRAT (SEQ ID NO:
- 5);
- and
- (f) a CDR-L3 comprising the amino acid sequence of QRYGSSYT (SEQ ID NO:
- 6).
10 more elements
An antibody that specifically binds to rabies virus G protein, wherein the antibody comprises a VH domain comprising the amino acid sequence of SEQ ID NO:
- 15 and a VL domain comprising the amino acid sequence of SEQ ID NO:
- 16.
An antibody that specifically binds to rabies virus G protein, wherein the antibody comprises a heavy chain sequence comprising the amino acid sequence of SEQ ID NO:
- 17 and a light chain sequence comprising the amino acid sequence of SEQ ID NO:
- 18.
Dependencies are inferred from the claim text.