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US 10,450,314 B2Granted
Pteridine derivatives as modulators of ROR gamma
AssigneeBoehringer Ingelheim International GmbH
InventorsSteven Richard Brunette, Johanna Csengery, Robert Owen Hughes, Xiang Li, Robert Sibley, Michael Robert Turner, Zhaoming Xiong
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Abstract
The present invention encompasses compounds of formula (I) wherein the variables are defined herein which are suitable for the modulation of RORγ and the treatment of diseases related to the modulation of RORγ. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.
Claims9
A compound of formula (I)
- wherein:
- R′ is selected from —S(O)nR6, —S(O)nNR7R8, and —S(O)(NH)R6;
- wherein:
- R6 is:
- C1-3 alkyl
- R7 and R8 are each H;
- and
- n is 1 or 2;
- R2 and R3 are independently selected from
- C1-3 alkyl;
- cyclopropyl;
- and
- methoxy;
- R4 is C1-6 alkyl, optionally substituted with one or two groups independently selected from
- C3-6 cycloalkyl;
- halogen;
- —CF3;
- and
- —CN;
- R5 is selected from
- C1-3 alkyl, optionally substituted with 1 to 3 fluoro groups;
- —CH2OH;
- —CH2OC(O)C1-3 alkyl;
- and
- —OC1-3 alkyl;
- W is selected from
- pyridinyl;
- pyrimidinyl;
- pyrizinyl;
- phenyl;
- and
- piperidinyl;
- and the pharmaceutically acceptable salts thereof.
30 more elements
Dependencies are inferred from the claim text.