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US 10,450,280 B2Granted
Tetrazolones as a carboxylic acid bioisosteres
AssigneeRigel Pharmaceuticals, Inc.
InventorsMatthew Duncton, Rajinder Singh
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Abstract
The present disclosure provides compounds that include a tetrazolone derivative of a carboxyl group of an active agent. This disclosure also relates to pharmaceutical compositions that include these compounds, methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
Claims7
A method of treating a disease or disorder in a subject in need of treatment, the method comprising:
- a) determining that a compound comprising a tetrazolone derivative of a carboxyl group of an active agent has biological activity that is about equal or superior to that of the active agent;
- and
- b) administering to the subject the compound comprising the tetrazolone derivative of a carboxyl group of an active agent,
- wherein the active agent is associated with the disease or disorder to be treated.
1 more element
Dependencies are inferred from the claim text.