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US 10,450,275 B2Granted
Compounds and methods for treating cancer, neurological disorders, ethanol withdrawal, anxiety, depression, and neuropathic pain
AssigneeBoard of Regents, The University of Texas System
InventorsStephen F. Martin, James J. Sahn, Luisa Scott, Jonathan Thomas Pierce-Shimomura
Life of this patent
Estimating the term…
Abstract
Provided herein, inter alia, are compounds and methods of treating diseases including cancer, neurological disease, alcohol withdrawal, depression and anxiety, and neuropathic pain.
Claims14
A compound having the formula:
- wherein:
- R2 is halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —C(O)R4, —OR4, —NR4R4A, —C(O)OR4, —C(O)NR4R4A, —NO2, —SR4, —S(O)n2R4, —S(O)n2OR4, —S(O)n2NR4R4A, —NHNR4R4A, —ONR4R4A, —NHC(O)NHNR4R4A, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- n2 is 1 or 2;
- R4, R4A are independently hydrogen, oxo, halogen, —CF3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —S(O)2Cl, —S(O)3H, —S(O)4H, —S(O)2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHS(O)2H, —NHC(O)H, —NHC(O)—OH, —NHOH, —OCF3, —OCHF2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- R3B is —CF3, —CN, —OH, —NH2, —CONH2, —S(O)3H, —S(O)2NH2, —NHC(O)NH2, —NHC(O)H, —OCHF2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
- with the proviso that the compound is not
3 more elements
Dependencies are inferred from the claim text.